In one of the largest studies to date on autism, researchers have identified 102 genes linked to the disorder, including 30 previously unconnected genes.
Led by the director of the Seaver Autism Center for Research and Treatment at Mount Sinai, Joseph Buxbaum, the study used advanced genetic sequencing technologies and analyzed over 35,000 samples, including nearly 12,000 from individuals with autism.
By comparing genetic sequences from affected individuals to their siblings and unaffected individuals, both inherited and de novo gene mutations were identified. The study distinguished genes specific to autism from those associated with other neurodevelopmental disorders.
The identified genes play a role in gene expression, communication between neurons, and cognitive and social cognition in autism. Understanding the molecular mechanisms of these genes may lead to new treatments for severe autism symptoms.
The findings highlight the complexity of autism and the need for personalized treatment strategies based on the individual’s specific genetic factors.
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